Diabetes & Islet Biology
We also work with cadaveric human pancreatic islets, biliary duct, gallbladder as well as brain-derived human cells to gather the information that would help us understand the regulation of insulin gene expression. Our previous studies using next-generation sequencing of developing human pancreas using the SOLiD platform have provided insight to understanding the role of ncRNAs (specifically microRNAs) in the development and differentiation of insulin-producing cells. Present research projects involve applying this information to the differentiation of human pancreatic progenitor cells. In addition to these studies, other projects in the lab are focused on understanding the epigenetic modifications in insulin-producing cells in a unique model of multigeneration undernutrition. These studies involve understanding the influence of diet, micronutrients, intrauterine programming, and gut microbiota in the development of central adiposity, insulin resistance, and type 2 diabetes.